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Published on: November 10, 2021
Platelet-derived growth factor and renal disease
Taizo Nakagawa1, Hiroshi Inoue, Masakiyo Sasahara
1The Second Department of Internal Medicine, University of Toyama, Toyama, Japan. taizo@med.u-toyama.ac.jp
Current Opinion in Nephrology and Hypertension
|November 30, 2011
Summary
Platelet-derived growth factor receptor-β (PDGFR-β) signaling is key in glomerular diseases like IgA nephropathy. Targeting PDGFR-β offers therapeutic potential, but further research is needed for effective treatments.
Area of Science:
- Nephrology
- Cell signaling
- Molecular biology
Background:
- Glomerular diseases are a significant cause of kidney damage.
- Platelet-derived growth factor (PDGF) signaling plays a crucial role in kidney development and disease.
- Understanding PDGF's specific roles is vital for developing targeted therapies.
Purpose of the Study:
- To review recent advances in understanding PDGF's role in glomerular diseases.
- To evaluate the therapeutic potential of targeting PDGF signaling pathways.
Main Methods:
- Review of current literature on PDGF and glomerular disease.
- Analysis of studies utilizing novel PDGFR-β targeting mouse models.
- Examination of evidence for PDGFR-α and other growth factor involvement.
Main Results:
- PDGF receptor-β (PDGFR-β) signaling is critically involved in glomerular disease pathogenesis, including IgA nephropathy.
- Targeting PDGFR-β is a potential therapeutic strategy, though current antagonists lack specificity and long-term data.
- Novel mouse models reveal PDGFR-β's postnatal role in aging-related mesangial sclerosis and kidney remodeling.
- Evidence suggests growth factor signal redundancy and potential roles for PDGFR-α.
Conclusions:
- Intervention in growth factor signaling pathways represents a promising therapeutic avenue for kidney glomerular diseases.
- Further research is essential to fully elucidate disease pathogenesis and develop successful targeted therapies.
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