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Updated: May 27, 2026
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
Malignant Brenner tumor of the ovary with transformation to trabecular carcinoid: an immunocytochemical and electron
Lawrence Max Roth1, Michael P Goheen, John R Broshears
1Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA. lroth@iupui.edu
Abstract:
Ovarian Brenner tumors are typically of surface epithelial-stromal origin; however, cases associated with mature cystic teratoma and/or struma ovarii possibly have a teratomatous derivation. Although argyrophil cells have been described in ovarian Brenner tumors and in urinary bladder epithelium, we are not aware of any previous reports of carcinoid arising from a malignant Brenner tumor of the ovary. In this study, we describe an 85-year-old woman who had a low-grade malignant Brenner tumor with progressive proliferation of neuroendocrine cells and transformation to trabecular carcinoid as demonstrated by immunocytochemistry and electron microscopy.
