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Blood magnesium parameters do not differ with age.

X Y Yang1, J M Hosseini, M E Ruddel

  • 1Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892.

Journal of the American College of Nutrition
|August 1, 1990
PubMed
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Blood magnesium levels in plasma, red blood cells (RBCs), and mononuclear blood cells (MBCs) remain stable across different age groups. This study found no significant age-related variations in these key magnesium parameters in healthy individuals aged 11-75.

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Chemistry

Background:

  • The influence of aging on blood magnesium (Mg) levels is not well-established.
  • Magnesium is a critical electrolyte involved in numerous physiological processes.

Purpose of the Study:

  • To investigate the relationship between age and blood magnesium parameters.
  • To determine if plasma, red blood cell (RBC), and mononuclear blood cell (MBC) magnesium levels change with age.

Main Methods:

  • Magnesium levels were measured in plasma, RBCs, and MBCs of 104 healthy volunteers (ages 11-75).
  • Mononuclear blood cells (MBCs) were isolated using Ficoll-Hypaque density gradient centrifugation.
  • Statistical analysis (ANOVA) was employed to compare Mg parameters across age groups.

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Main Results:

  • Mean plasma Mg: 1.63 +/- 0.01 mEq/L
  • Mean RBC Mg: 4.55 +/- 0.06 mEq/L
  • Mean MBC Mg content: 72.8 +/- 1.0 fg/cell
  • Mean MBC Mg concentration: 19.6 +/- 0.3 mEq/L
  • No statistically significant differences (p > 0.05) were observed in any Mg parameter across age intervals.

Conclusions:

  • Blood magnesium parameters, including plasma, RBC, and MBC levels, do not significantly vary with age in healthy individuals aged 11 to 75 years.
  • These findings suggest that age is not a confounding factor for these specific blood magnesium measurements.