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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Related Experiment Video

Updated: May 27, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multiple myeloma-amyloidosis presenting as pseudomyopathy.

Mário Sérgio F Santos1, Bianca Soares, Osvaldo Mendes

  • 1Universidade de São Paulo – USP. m.cla@uol.com.br

Revista Brasileira De Reumatologia
|November 30, 2011
PubMed
Summary

Amyloidosis, a condition of amyloid fibril deposition, often presents after age 40. This case highlights amyloidosis linked to multiple myeloma, mimicking pseudomyopathy in a patient.

Related Experiment Videos

Last Updated: May 27, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

  • Rheumatology
  • Hematology
  • Pathology

Background:

  • Amyloidosis involves amyloid fibril deposition in tissues, typically after age 40.
  • It can manifest systemically or locally, often associated with multiple myeloma or chronic inflammatory conditions.
  • Amyloidosis can present with symptoms mimicking various rheumatic syndromes.

Observation:

  • A case study of a patient with amyloidosis.
  • The patient's condition was associated with multiple myeloma.
  • The patient exhibited clinical characteristics suggestive of pseudomyopathy.

Findings:

  • Amyloidosis associated with multiple myeloma can present as pseudomyopathy.
  • This case underscores the diverse clinical presentations of amyloidosis.
  • Diagnostic challenges arise when amyloidosis mimics other rheumatic conditions.

Implications:

  • Highlights the importance of considering amyloidosis in patients with unexplained myopathy.
  • Emphasizes the link between multiple myeloma and amyloidosis.
  • Suggests the need for thorough investigation in rheumatic syndromes that do not respond to typical treatments.