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Updated: May 27, 2026

Automated HPLC Separation Using LC-Mate: An Integrated Repetitive Autosampler and Fraction Collector for Microscale Purification
Published on: February 27, 2026
Completely automated in-syringe dispersive liquid-liquid microextraction using solvents lighter than water
Fernando Maya1, José Manuel Estela, Víctor Cerdà
1Department of Chemistry, Faculty of Sciences, University of the Balearic Islands, Carretera de Valldemossa km 7.5, 07122 Palma de Mallorca, Illes Balears, Spain.
Abstract:
This paper describes the development of a new multisyringe flow injection analysis set-up that enables the complete automation of the dispersive liquid-liquid microextraction (DLLME) technique using solvents lighter than water. Its hyphenation with a liquid chromatographic separation is implemented using a single multisyringe pump obtaining a compact, simple, easy to operate, and fast instrument. DLLME is carried out with a throughput of 42 h(-1) and DLLME for the extraction of benzo(a)pyrene and its subsequent chromatographic determination can be carried out with an analysis throughput of 7 h(-1).
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