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Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
Published on: September 11, 2012
Diagnosis, treatment, and prevention of anal cancer
Subhashis Mitra1, Lawrence Crane
1Division of Infectious Diseases, Wayne State School of Medicine, 3990 John R, 5 Hudson, Detroit, MI, 48201, USA, smitr@med.wayne.edu.
Abstract:
Rare in the general population, anal cancer has reached epidemic proportions among HIV-infected men who have sex with men (MSM). These cancers are human papillomavirus (HPV)-associated, usually HPV type16, and are analogous to cervical cancer. At present, the rates of anal cancer in this group are 10-fold higher than that of cervical cancer occurring in women in the general population. Although there are no national guidelines for screening for anal intraepithelial dysplasia (AIN), many large HIV clinics are now performing anal cytologic screening in their at-risk patients. This paper outlines the current approach to screening for AIN and its management.
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