Related Experiment Video
Updated: May 27, 2026
07:17
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Cellular and molecular changes in orthodontic tooth movement.
Shahrul Hisham Zainal Ariffin1, Zulham Yamamoto, Intan Zarina Zainol Abidin
1School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia. shahroy8@gmail.com
Thescientificworldjournal
|November 30, 2011
Summary
Biomarkers from dental tissues can monitor orthodontic tooth movement and related bone remodeling. Identifying these biological markers may help improve treatment efficiency and reduce side effects.
Area of Science:
- Biomaterials Science
- Orthodontics
- Periodontology
Background:
- Orthodontic treatment induces complex biological responses in periodontal tissues and alveolar bone.
- Understanding these responses is crucial for optimizing treatment and minimizing adverse effects.
- Various substances released during tooth movement are potential biomarkers for monitoring these processes.
Purpose of the Study:
- To review tissue changes during orthodontic tooth movement.
- To identify and propose potential biomarkers associated with these changes.
- To explore the role of stem cells in orthodontic treatment.
Main Methods:
- Review of literature on tissue reactions during orthodontic tooth movement.
- Analysis of cellular and molecular events in compression and tension zones.
- Identification of biomarkers related to bone remodeling, inflammation, and root resorption.
Main Results:
- Detailed description of tissue changes in compression and tension regions, including osteoblast and osteoclast activity.
- Explanation of stem cell differentiation into osteoblasts and osteoclasts.
- Proposal of several biomarkers for bone remodeling, inflammation, and root resorption.
Conclusions:
- Biomarkers can effectively represent biological changes during orthodontic tooth movement.
- Knowledge of these biomarkers may lead to accelerated orthodontic treatment.
- Further research into biomarker validation is warranted.
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