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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

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Related Experiment Video

Updated: May 27, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast Cell Proteases and Inflammation.

Hongyan Dai1, Ronald J Korthuis

  • 1Department of Medical Pharmacology and Physiology and Dalton Cardiovascular Research Center, University of Missouri, School of Medicine, Columbia, Missouri 65212.

Drug Discovery Today. Disease Models
|November 30, 2011
PubMed
Summary
This summary is machine-generated.

Mast cells release proteases that contribute to inflammation and tissue damage in various diseases. Understanding these mast cell proteases is key to developing new treatments for inflammatory conditions.

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Related Experiment Videos

Last Updated: May 27, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

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Published on: July 4, 2018

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Mast cells are recognized for their role in allergic reactions.
  • They also contribute to inflammatory conditions via mediators like proteases.
  • Mast cell proteases' substrate specificity and action are of significant interest.

Purpose of the Study:

  • To explore the role of mast cell proteases in inflammatory conditions.
  • To understand the molecular mechanisms underlying mast cell-mediated inflammation.
  • To identify potential therapeutic targets for inflammatory diseases.

Main Methods:

  • Analysis of mast cell protease activity.
  • Investigation of substrate specificity.
  • Examination of tissue distribution and mode of action.
  • Review of existing literature on mast cell proteases in disease pathogenesis.

Main Results:

  • Mast cell proteases are abundant and cleave numerous proteins, modifying tissue function.
  • Dysregulated release of these proteases contributes to diseases like asthma, arthritis, and atherosclerosis.
  • Mast cell proteases play a critical role in host defense but require regulation to prevent self-damage.

Conclusions:

  • Mast cell proteases are crucial mediators in both host defense and inflammatory diseases.
  • Understanding their function is vital for unraveling immunologic disorders.
  • Targeting mast cell proteases offers potential for novel therapeutic strategies.