A review of clinical profile in sickle cell traits

Sickle cell trait is not usually regarded as a disease state because it has complications that are either uncommon or mild. Nevertheless, under unusual circumstances, serious morbidity or mortality can result from complications related to polymerization of deoxy-hemoglobin S. A previous study was earlier conducted to study Sickle cell traits and it revealed that there was enhanced lipid per oxidation along with imbalance in the pro-oxidant and antioxidant status in patients with sickle cell anaemia. Moreover, sickle cell traits present with varied problems including increased urinary tract infection in women, gross hematuria, complications of hyphema, splenic infarction with altitude hypoxia or exercise, life-threatening complications of exercise etc. Renal medullary carcinoma in the young, early onset of end stage renal, as well as disease from autosomal dominant polycystic kidney disease are other well-known occurrences in sickle cell traits. In view of the above facts, this article aims to review the literature to analyze the health status in sickle cell traits.