Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 27, 2026

Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion
05:43

Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion

Published on: January 24, 2017

Preparation of Eudragit E100 microspheres by modified solvent evaporation method.

Vandana Singh1, Amrendra Kumar Chaudhary

  • 1Translam Institute of Pharm Education and Research, Meerut, UP-250001, India. vandankhushi@gmail.com

Acta Poloniae Pharmaceutica
|December 1, 2011
PubMed
Summary

Researchers developed hollow microspheres, a novel floating drug delivery system, for sustained ranitidine hydrochloride release. These microspheres offer prolonged stomach retention and enhanced drug bioavailability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The PERK-GADD45A axis is a key driver of hepatic stellate cell activation.

Hepatology communications·2026
Same author

Quercetin Affects Carcinogenic Phenotype of Breast and Lung Cancer Cells Differentially Through Sterol Regulation Mediated by MALAT1 Perturbation.

Chemistry, an Asian journal·2026
Same author

Degradation dynamics: an insight into microbial interactions with explosive compounds.

Biodegradation·2026
Same author

Empowering molecular complexity <i>via</i> biocatalysis: emerging blueprints in the total synthesis of medicinally relevant natural products.

RSC medicinal chemistry·2026
Same author

Kuwanons from Mulberry (Morus spp.): Exploring their structural activity relationship, biosynthesis, and biological properties.

Fitoterapia·2026
Same author

Late stage O-glycosylation: A strategic gateway to complex therapeutic natural products.

Advances in carbohydrate chemistry and biochemistry·2025

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Gastroretentive drug delivery systems aim to prolong drug release and improve therapeutic efficacy.
  • Ranitidine hydrochloride is a widely used medication for acid-related gastrointestinal disorders.

Purpose of the Study:

  • To develop hollow microspheres as a novel floating drug delivery system (FDDS) for ranitidine hydrochloride.
  • To achieve prolonged gastric retention time and sustained drug release.
  • To enhance the bioavailability of ranitidine hydrochloride.

Main Methods:

  • Hollow microspheres loaded with ranitidine hydrochloride were prepared using the solvent evaporation method.
  • Eudragit RLPO was utilized as the polymer, dissolved in a dichloromethane and ethanol mixture.

More Related Videos

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles
08:53

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles

Published on: September 19, 2025

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
10:54

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

Related Experiment Videos

Last Updated: May 27, 2026

Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion
05:43

Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion

Published on: January 24, 2017

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles
08:53

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles

Published on: September 19, 2025

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
10:54

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

  • Optimization involved varying polymer viscosity and drug-polymer ratio.

    • Main Results:

    • The maximum yield of hollow microspheres was 88.45% with a drug loading of 80 ± 4.0%.
    • In vitro studies demonstrated sustained drug release for approximately 24 hours.
    • The microspheres exhibited buoyancy in simulated gastric fluid for over 12 hours.

    Conclusions:

    • Ranitidine hydrochloride hollow microspheres represent a promising FDDS for sustained drug delivery.
    • The developed system can prolong drug release and enhance bioavailability.
    • This formulation offers potential for improved patient compliance and therapeutic outcomes.