Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperbaric oxygen as adjunctive therapy for osteomyelitis.

J T Mader1, K R Adams, W R Wallace

  • 1University of Texas Medical Branch, Galveston.

Infectious Disease Clinics of North America
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissolved carbon dioxide and oxygen concentrations in purge of vacuum-packaged pork chops and the relationship to shelf life and models for estimating microbial populations.

Meat science·2015
Same author

Adult chronic osteomyelitis.

Orthopedics·2014
Same author

Summation.

Anesthesia progress·2009
Same author

Revised guidelines for teaching the comprehensive control of pain and anxiety in dentistry.

Anesthesia progress·2009
Same author

Regional CBF in chronic stable TBI treated with hyperbaric oxygen.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2005
Same author

Frequency and causes of osteoporosis in men.

Rheumatology (Oxford, England)·2003
Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026
Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026
Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026
Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026
Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026
Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026
See all related articles

Hyperbaric oxygen therapy (HBOT) enhances bone infection healing by increasing tissue oxygen levels. This treatment aids immune cell function, promotes wound healing, and combats anaerobic bacteria, proving beneficial for severe osteomyelitis.

Area of Science:

  • Hyperbaric medicine
  • Infectious diseases
  • Orthopedic surgery

Background:

  • Osteomyelitis is a challenging bone infection requiring effective treatment strategies.
  • Hyperbaric oxygen (HBO) therapy is mechanistically proposed to aid osteomyelitis treatment.
  • Adequate tissue oxygenation is crucial for host defense and wound healing.

Purpose of the Study:

  • To elucidate the mechanisms by which hyperbaric oxygen (HBO) may benefit osteomyelitis treatment.
  • To highlight the role of HBO in enhancing oxygen-dependent microbial killing and tissue repair.
  • To present the clinical application of adjunctive HBO in severe osteomyelitis cases.

Main Methods:

  • Review of the physiological effects of hyperbaric oxygen on infected tissues.

Related Experiment Videos

  • Discussion of HBO's impact on polymorphonuclear leukocyte function and fibroblast activity.
  • Examination of HBO's direct antimicrobial effects and synergistic action with antibiotics.

    • Main Results:

    • HBO increases oxygen tension in infected bone, supporting immune cell function.
    • HBO promotes angiogenesis and fibroblast activity essential for wound healing.
    • HBO exhibits direct antimicrobial effects against anaerobic bacteria and potentiates antibiotic efficacy against Pseudomonas aeruginosa.

    Conclusions:

    • Hyperbaric oxygen therapy offers a promising adjunctive treatment for osteomyelitis by enhancing oxygen delivery and host defense mechanisms.
    • HBO's multifaceted effects, including antimicrobial activity and support for tissue repair, make it valuable for managing complex bone infections.
    • Clinical use of adjunctive HBO for advanced osteomyelitis stages (Cierny Mader 3B and 4B) is supported by its proposed mechanisms of action.