Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chiral-Induced Spin Selectivity Effect in a 1 nm Thin 1,1'-Binaphthyl-2,2'-diyl Hydrogenphosphate Self-Assembled Monolayer on Nickel Oxide.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Selective Narrowing of the Bonding Modes of Plasmonic Nanoantennas.

ACS applied materials & interfaces·2026
Same author

Dynamic breaking of mirror symmetry in spin-dependent electron transport through chiral media causes enantiomeric excesses.

Science advances·2026
Same author

Single-molecule fluorescence spectroscopy of fast protein dynamics.

Current opinion in structural biology·2026
Same author

Why Is the Mechanism Underlying the Chiral-Induced Selectivity Effect Still Challenging?

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A stochastic mechanism drives fast substrate translocation in the AAA+ machine ClpB.

Nature communications·2026

Related Experiment Video

Updated: May 27, 2026

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method

Published on: December 1, 2015

Detection and quantification through a lipid membrane using the molecularly controlled semiconductor resistor.

Danny Bavli1, Maria Tkachev, Hubert Piwonski

  • 1Department of Chemical Physics, Weizmann Institute of Science, Rehovot, 76100, Israel.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 1, 2011
PubMed
Summary

Researchers developed a novel semiconductor resistor (MOCSER) for direct electrical detection of biomolecular binding events on lipid membranes. This miniaturizable sensor enables sensitive, real-time monitoring of protein-membrane interactions without sample transfer, advancing biochemical analysis.

More Related Videos

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
08:07

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy
10:59

Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy

Published on: May 28, 2021

Related Experiment Videos

Last Updated: May 27, 2026

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method

Published on: December 1, 2015

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
08:07

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy
10:59

Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy

Published on: May 28, 2021

Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Detecting molecular binding to biomembranes is crucial in biochemistry and analytical chemistry.
  • Existing methods like fluorescence and SPR require sample transfer and lack miniaturization.
  • A need exists for sensitive, in-situ detection methods for biomembrane interactions.

Purpose of the Study:

  • To introduce a novel semiconductor-based sensor for direct electrical detection of biomolecular interactions on lipid bilayer membranes.
  • To demonstrate the sensor's capability for monitoring pH, amino acid concentration, and protein binding events.
  • To establish a miniaturizable and sensitive platform for studying protein-membrane interactions.

Main Methods:

  • Utilized an n-type Gallium Arsenide (GaAs)-based molecularly controlled semiconductor resistor (MOCSER) with an adsorbed lipid bilayer membrane.
  • Protected the GaAs device with a methoxysilane thin film to prevent etching in aqueous environments.
  • Incorporated biotinylated lipids into the membrane to detect streptavidin/avidin binding and subsequent antibody interactions.

Main Results:

  • The MOCSER system successfully detected changes in pH and amino acid concentrations in aqueous solutions.
  • Demonstrated sensitive and selective detection of streptavidin/avidin binding to biotinylated lipid membranes.
  • Showcased the ability to detect streptavidin antibodies binding to immobilized streptavidin on the modified sensor.
  • Observed that the sensor's response is dependent on the analyte's charge.

Conclusions:

  • The developed MOCSER device offers a novel, facile electrical method for detecting protein-membrane interactions.
  • This approach provides a sensitive, miniaturizable, and direct detection platform for biochemical and analytical studies.
  • The findings pave the way for advanced electrical biosensing applications in studying biomolecular recognition events.