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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

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Genomic Imprinting and Inheritance

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Related Experiment Video

Updated: May 27, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

Epigenomic deregulation in the immune system.

Virginia C Rodriguez-Cortez¹, Henar Hernando, Lorenzo de la Rica

¹Cancer Epigenetics & Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

|December 1, 2011

Summary

This summary is machine-generated.

Epigenetic alterations are crucial in immune system disorders. Understanding these epigenetic changes through epigenomic analysis can reveal disease mechanisms and guide clinical applications.

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Last Updated: May 27, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

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Published on: November 4, 2016

Area of Science:

Immunology
Epigenetics
Molecular Biology

Background:

Immune function relies on precise cell differentiation and activation control.
Transcriptional deregulation in immune cells can cause hematological malignancies, autoimmune diseases, and immunodeficiencies.
Epigenetic regulation is vital for immune cell identity and function, with deregulation linked to various diseases.

Purpose of the Study:

To review current knowledge on epigenetic alterations in immune system disorders.
To discuss the role of epigenomic analysis in understanding disease mechanisms.
To explore the clinical potential of epigenomic insights.

Main Methods:

Literature review of epigenetic alterations in immune disorders.
Discussion of epigenomic analysis techniques.
Exploration of clinical applications of epigenomic data.

Main Results:

Epigenetic deregulation arises from genetic changes or environmental factors.
Genetic predisposition, viral infections, and external factors contribute to immune diseases.
Significant progress in understanding genetic contributions, but less in epigenetic factors.

Conclusions:

Epigenetic factors play a critical role in immune system disorders.
Epigenomic analysis offers valuable insights into disease etiology.
This knowledge can potentially be translated for clinical use.