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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: May 27, 2026

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
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Development of surface-functionalised nanoparticles for FGF2 receptor-based solid tumour targeting.

Amit Jain1, Arvind Gulbake, Ashish Jain

  • 1Pharmaceutics Research Project Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. drskjainin@yahoo.com

Journal of Microencapsulation
|December 1, 2011
PubMed
Summary

Surface-functionalised gelatin nanoparticles (GNPs) were developed to target breast cancer cells overexpressing fibroblast growth factor-2 (FGF2) receptors. Heparin-functionalised GNPs (H-GNPs) showed enhanced uptake in cancer cells, suggesting their potential as effective solid tumor drug carriers.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Breast cancer cells often overexpress fibroblast growth factor-2 (FGF2) receptors.
  • Targeted drug delivery systems are crucial for improving breast cancer treatment efficacy.
  • Gelatin nanoparticles (GNPs) offer a biocompatible platform for drug encapsulation.

Purpose of the Study:

  • To develop and characterize surface-functionalised gelatin nanoparticles (GNPs) for targeted delivery of cisplatin to breast cancer.
  • To investigate the targeting potential of heparin-functionalised GNPs (H-GNPs) utilizing FGF2 receptor overexpression.

Main Methods:

  • Gelatin nanoparticles (GNPs) were prepared using a two-step desolvation method.
  • GNPs were surface-functionalised with activated heparin.
  • Characterization included surface morphology, particle size, charge, drug entrapment, and in vitro drug release.
  • In vitro cell uptake studies were performed on human breast cancer MDA-MB-231 cells.

Main Results:

  • The mean diameter of GNPs was 173 ± 2.2 nm, increasing to 189 ± 3.4 nm after heparin conjugation (H-GNPs).
  • Characterization confirmed successful heparin functionalisation and nanoparticle integrity.
  • In vitro studies demonstrated significantly greater uptake of H-GNPs compared to unmodified GNPs in MDA-MB-231 cells.

Conclusions:

  • Heparin-functionalised gelatin nanoparticles (H-GNPs) show enhanced targeting of breast cancer cells overexpressing FGF2 receptors.
  • H-GNPs are a promising nanocarrier system for targeted delivery of chemotherapeutic agents like cisplatin in solid tumors.
  • This approach holds potential for improving therapeutic outcomes in breast cancer treatment.