Related Experiment Videos
Post-translational polymorphism of human IgA identified by immunoisoelectrofocusing
G De Benedictis1, G Rose, C Brancati
1Department of Cell Biology, University of Calabria, Arcavacata, CS, Italy.
Journal of Immunogenetics
|February 1, 1990
Abstract:
Immunoisoelectrofocusing (IIEF) reveals a microheterogeneity of human serum IgA controlled by an autosomal polymorphic gene, termed S. The microheterogeneity disappears when sialic acid is removed from serum glycoproteins by neuraminidase treatment. It can be postulated, therefore, that S encodes a sialyltransferase which attaches sialic acid at the outer prosthetic chains of IgA.