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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Molecular targeted agents for gastric and gastroesophageal junction cancer

Takashi Oshima1, Munetaka Masuda

  • 1Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan. ohshimatakashi@yahoo.co.jp

Surgery Today
|December 1, 2011
PubMed

Insights

Advanced stomach and gastroesophageal junction (GEJ) cancers need better treatments. This review explores molecular targeted therapies focusing on pathways like EGFR, VEGFR, and PI3K/Akt/mTOR for improved outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Advanced gastric and gastroesophageal junction (GEJ) cancers present significant treatment challenges with poor clinical outcomes despite current therapies.
  • Cancer cell proliferation, invasion, and metastasis are critical processes driving disease progression.

Purpose of the Study:

  • To review recent advancements in molecular targeted therapy for gastric and GEJ cancers.
  • To highlight key molecular pathways and their potential as targets for novel therapeutic agents.

Main Methods:

  • Literature review focusing on molecular targeted agents and relevant pathways in gastric and GEJ cancer.
  • Analysis of current research on epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), PI3K/Akt/mTOR, insulin-like growth factor receptor (IGFR), c-Met, and fibroblast growth factor receptor (FGFR) pathways.

Main Results:

  • Several molecular pathways, including EGFR, VEGFR, PI3K/Akt/mTOR, IGFR, c-Met, and FGFR, are identified as promising targets for molecular targeted therapy.
  • These pathways are intimately related to cancer cell proliferation, invasion, and metastasis.

Conclusions:

  • Targeting specific molecular pathways offers a promising strategy for developing novel treatments for advanced gastric and GEJ cancers.
  • Further research and clinical development of these targeted agents are crucial for improving patient outcomes.

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