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Published on: February 10, 2023
Clinical Course of Asymptomatic Isolated Distal Deep Vein Thrombosis of the Leg: A Single-Institution Study
Nobuhiro Shimabukuro1, Makoto Mo1, Naoki Hashiyama1
1Department of Cardiovascular Surgery, Yokohama Minami Kyosai Hospital, Yokohama, Kanagawa, Japan.
Insights
Asymptomatic isolated distal deep vein thrombosis (DVT) generally shows a good prognosis. Most patients did not experience recurrence or extension, suggesting routine anticoagulation may not be necessary.
Area of Science:
- Vascular Medicine
- Phlebology
- Diagnostic Ultrasound
Background:
- The clinical course of asymptomatic isolated distal deep vein thrombosis (DVT) remains poorly understood.
- Distal DVT is diagnosed using sonography, but its natural history without anticoagulant treatment requires further investigation.
Purpose of the Study:
- To elucidate the 3-month and 1-year clinical outcomes for patients diagnosed with asymptomatic isolated distal DVT of the leg.
- To evaluate the recurrence and extension rates of distal DVT in patients not receiving anticoagulant therapy.
Main Methods:
- Retrospective evaluation of 127 patients with asymptomatic, sonographically confirmed isolated distal DVT.
- Patients did not receive anticoagulant therapy and were followed for 3 months and 1 year with serial sonographic examinations.
Main Results:
- No venous thromboembolism recurrence was observed in any patient during the follow-up period.
- Thrombus extension to proximal veins was confirmed in only 2 out of 43 patients who underwent repeat ultrasound.
Conclusions:
- Asymptomatic isolated distal DVT of the leg demonstrates a favorable prognosis.
- Uniform anticoagulation therapy is likely unnecessary for this patient group, supporting a conservative management approach.
Abstract:
Background: The natural history of asymptomatic isolated distal deep vein thrombosis (DVT) of the leg is unclear. This study aimed to describe a 3-month and 1-year clinical course after diagnosis of asymptomatic isolated distal DVT of the leg. Methods: This study included 127 patients with asymptomatic, sonographically proven isolated distal DVT who did not receive anticoagulant therapy and were retrospectively evaluated at our hospital between May 2014 and September 2016. After 3 months and 1 year, the presence or absence of venous thromboembolism recurrence and extension of DVT toward proximal veins was sonographically confirmed. Results: At 3-month and 1-year follow-ups, 125 and 109 patients were observed, respectively. All patients showed no symptoms or findings suspecting venous thromboembolism recurrence during the observation period. However, 43 patients underwent repeat ultrasonic examination, and thrombus extension was confirmed in 2 patients. Conclusions: Asymptomatic isolated distal DVT of the leg showed good prognosis, and thus uniform anticoagulation therapy was considered unnecessary. (This is a translation of Jpn J Phlebol 2018; 29(3): 309-314.).
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