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08:03
Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain
Published on: March 10, 2026
[Primary cranial vault lymphoma]
Daniel Castro-Bouzas1, Ángel Prieto-González, Ramón Serramito-García
1Servicio de Neurocirugía, Departamento de Cirugía, Universidad de Santiago de Compostela, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, España. danicastrobouzas@yahoo.es
Revista De Neurologia
|December 1, 2011
Summary
This study reports a rare case of ALK-negative primary large-cell lymphoma in the cranial vault. Further research is needed to understand this uncommon bone lymphoma presentation.
Area of Science:
- Oncology
- Hematology
- Skeletal Tumors
Background:
- Primary bone lymphomas are rare, constituting 3-7% of malignant bone tumors and <2% of adult lymphomas.
- Lymphomas primarily affecting the cranial vault are exceptionally infrequent.
Observation:
- A 59-year-old female presented with a painful cranial vault tumor.
- The tumor was surgically removed and diagnosed as an anaplastic lymphoma kinase (ALK)-negative primary large-cell lymphoma.
Findings:
- This case represents a primary large-cell lymphoma of the cranial vault.
- The study investigated the translocation of the ALK gene in this specific lymphoma type.
Implications:
- This case highlights the importance of considering rare lymphomas in cranial vault tumor differential diagnoses.
- Further investigation into ALK gene status in cranial vault lymphomas may offer prognostic and therapeutic insights.
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