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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Updated: May 27, 2026

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain
08:03

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain

Published on: March 10, 2026

[Primary cranial vault lymphoma].

Daniel Castro-Bouzas1, Ángel Prieto-González, Ramón Serramito-García

  • 1Servicio de Neurocirugía, Departamento de Cirugía, Universidad de Santiago de Compostela, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, España. danicastrobouzas@yahoo.es

Revista De Neurologia
|December 1, 2011
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of ALK-negative primary large-cell lymphoma in the cranial vault. Further research is needed to understand this uncommon bone lymphoma presentation.

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Area of Science:

  • Oncology
  • Hematology
  • Skeletal Tumors

Background:

  • Primary bone lymphomas are rare, constituting 3-7% of malignant bone tumors and <2% of adult lymphomas.
  • Lymphomas primarily affecting the cranial vault are exceptionally infrequent.

Observation:

  • A 59-year-old female presented with a painful cranial vault tumor.
  • The tumor was surgically removed and diagnosed as an anaplastic lymphoma kinase (ALK)-negative primary large-cell lymphoma.

Findings:

  • This case represents a primary large-cell lymphoma of the cranial vault.
  • The study investigated the translocation of the ALK gene in this specific lymphoma type.

Implications:

  • This case highlights the importance of considering rare lymphomas in cranial vault tumor differential diagnoses.
  • Further investigation into ALK gene status in cranial vault lymphomas may offer prognostic and therapeutic insights.