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Use of ethylene glycol to evaluate gradient performance in gradient-intensive diffusion MR sequences
William M Spees1, Sheng-Kwei Song, Joel R Garbow
1Department of Radiology, Washington University, St Louis, Missouri 63110, USA. spees@wustl.edu
Magnetic Resonance in Medicine
|December 1, 2011
Summary
This study presents a novel method for calibrating magnetic resonance imaging (MRI) gradient strength using ethylene glycol. This approach offers wider dynamic range calibration and simultaneous temperature measurement, improving MRI accuracy.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Diffusion MRI
- Spectroscopy
Background:
- Standard MRI gradient calibration using phantoms has limitations in full-range characterization.
- Accurate gradient calibration is crucial for quantitative diffusion MRI techniques.
Purpose of the Study:
- To develop a more comprehensive method for MRI gradient strength calibration.
- To utilize a liquid with known temperature-dependent diffusion properties for calibration.
Main Methods:
- Measuring the apparent diffusion coefficient of ethylene glycol across a range of temperatures.
- Utilizing (1)H MR spectroscopy to simultaneously determine sample temperature and diffusion properties.
- Assessing gradient performance in diffusion-weighted imaging and spectroscopy sequences.
Main Results:
- Ethylene glycol's diffusion coefficient follows Arrhenius-type behavior within typical MRI magnet temperatures.
- Simultaneous temperature reporting via (1)H MR spectroscopy is demonstrated.
- Ethylene glycol's high viscosity is suitable for demanding diffusion sequences.
Conclusions:
- Ethylene glycol serves as an effective liquid for wide dynamic range MRI gradient calibration.
- This method provides simultaneous temperature measurement, enhancing calibration accuracy.
- The approach is well-suited for advanced diffusion-weighted MRI and spectroscopy applications.
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