Guiding the self-organization of random Boolean networks

Random Boolean networks (RBNs) are models of genetic regulatory networks. It is useful to describe RBNs as self-organizing systems to study how changes in the nodes and connections affect the global network dynamics. This article reviews eight different methods for guiding the self-organization of RBNs. In particular, the article is focused on guiding RBNs toward the critical dynamical regime, which is near the phase transition between the ordered and dynamical phases. The properties and advantages of the critical regime for life, computation, adaptability, evolvability, and robustness are reviewed. The guidance methods of RBNs can be used for engineering systems with the features of the critical regime, as well as for studying how natural selection evolved living systems, which are also critical.