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Dihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1-42) oligomers

Harry LeVine1, Levi Lampe, Lina Abdelmoti

  • 1Department of Cellular and Molecular Biochemistry, Center on Aging, Center for Structural Biology, University of Kentucky, Lexington, Kentucky 40506, United States. hlevine@email.uky.edu

Biochemistry
|December 2, 2011
PubMed
Summary

Certain benzoic acid derivatives can break apart amyloid-beta (Aβ) oligomers, while gallic acid stabilizes them. This research explores small molecules for potential Aβ oligomer dissociation therapies.

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