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Gold nanoparticles in biomedical applications: recent advances and perspectives
Lev Dykman1, Nikolai Khlebtsov
1Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr. Entuziastov, Saratov 410049, Russian Federation.
Chemical Society Reviews
|December 2, 2011
Summary
Gold nanoparticles (GNPs) offer versatile applications in medicine, including diagnostics, drug delivery, and therapies. This review details their use in biomedical fields, highlighting immunological properties and future challenges.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Gold nanoparticles (GNPs) possess tunable geometrical, optical, and surface properties.
- GNPs are increasingly utilized in diverse biological and medical applications.
Purpose of the Study:
- To critically review the applications of GNP conjugates in biomedical diagnostics, analytics, therapies, and molecular delivery.
- To summarize the immunological properties of GNPs, a distinct focus from other reviews.
Main Methods:
- Literature review of published examples and research on GNP applications.
- Discussion of basic principles, recent advances, and current challenges in the field.
Main Results:
- GNPs are employed in genomics, biosensorics, immunoassays, clinical chemistry, cancer photothermolysis, targeted drug delivery, and bioimaging.
- The review synthesizes information on GNP conjugates for diagnostics, photothermal/photodynamic therapies, and molecular delivery.
Conclusions:
- GNP conjugates show significant promise and diverse applications in modern medicine.
- Further research is needed to address current challenges and fully leverage GNP capabilities in biomedical settings.
