Related Experiment Video
Updated: May 27, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L
Wanxing Wei1, Xiangrong Li, Kuiwu Wang
1Department of Chemistry, Guangxi University, Nanning 530004, People's Republic of China. chewxwei@yahoo.com.cn
Abstract:
One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC₅₀ values for HBsAg of 9.5 µM (nirtetralin A), 16.7 µM (nirtetralin B) and 97.2 µM (nirtetralin), IC₅₀ values for HBeAg of 17.4 µM (nirtetralin A), 69.3 µM (nirtetralin B) and 232.0 µM (nirtetralin), respectively.
Related Concept Videos
Hepatitis
Viral Hepatitis I: Introduction
Cirrhosis I: Introduction
