Determination of Doxazosin Mesylate in Tablets by RP-HPLC
B Dhanya1, A Suganthi, A K Sen
1Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Waghodiya, Vadodara - 391 760, India.
Indian Journal of Pharmaceutical Sciences
|December 2, 2011
Abstract:
A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 μg/ml. The retention time of the drug was 3.8 min. The LOD and LOQ were found to be 0.1 μg/ml and 0.5 μg/ml, respectively.
