Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...

Barrett Esophagus-II: Clinical Manifestations and Management

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...

Endoscopic Procedures I: Esophagogastroduodenoscopy

Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:

Upper GI Series: Barium Swallow

Upper GI Series: Barium Swallow

The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term risk of death in patients with hidradenitis suppurativa.

International journal of dermatology·2022

Same author

Aspirin, Statins, Non-aspirin NSAIDs, Metformin, and the Risk of Biliary Cancer: A Swedish Population-Based Cohort Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2022

Same author

The Natural History of Chronic Unexplained Gastrointestinal Disorders and Gastroesophageal Reflux During 20 Years: A US Population-Based Study.

Mayo Clinic proceedings·2021

Same author

The relationship between learner engagement and teaching effectiveness: a novel assessment of student engagement in continuing medical education.

BMC medical education·2020

Same author

Cost analysis and complication profile of primary shoulder arthroplasty at a high-volume institution.

Journal of shoulder and elbow surgery·2020

Same author

Injury Rate and Patterns in Group Strength-Endurance Training Classes.

Mayo Clinic proceedings·2019

Search research articles

Related Experiment Video

Updated: May 27, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Population screening for barrett esophagus: a prospective randomized pilot study.

Joseph Y Chang¹, Nicholas J Talley, G Richard Locke

¹Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA. prasad.ganapathy@mayo.edu

Mayo Clinic Proceedings

|December 3, 2011

Summary

Unsedated transnasal endoscopy (uTNE) and video capsule endoscopy (VCE) show promise as feasible and safe alternatives for Barrett esophagus (BE) screening in the community. Participation rates were higher for these unsedated methods compared to sedated endoscopy.

More Related Videos

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Related Experiment Videos

Last Updated: May 27, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Area of Science:

Gastroenterology
Endoscopic screening
Esophageal diseases

Background:

Barrett esophagus (BE) screening traditionally uses sedated endoscopy (sEGD).
Investigating less invasive screening alternatives is crucial for community-based detection.
Patient acceptance and feasibility of unsedated methods require evaluation.

Purpose of the Study:

To assess the feasibility of unsedated transnasal endoscopy (uTNE) and video capsule endoscopy (VCE) as alternatives to sEGD for BE screening.
To estimate participation rates for sEGD, uTNE, and VCE in a community BE screening setting.
To evaluate the safety profiles of uTNE and VCE.

Main Methods:

Randomized trial involving patients over 50 without known BE.
Stratified randomization into three groups: sEGD, uTNE, or VCE.
Assessment of participation rates and safety outcomes.

Main Results:

Participation rates were 38% for sEGD, 50% for uTNE, and 59% for VCE.
Both uTNE and VCE were well-tolerated with no adverse events.
BE was detected in 3 patients, and esophagitis in 8 patients.

Conclusions:

Unsedated endoscopy techniques (uTNE, VCE) are feasible and safe alternatives for community BE screening.
Higher participation rates suggest improved patient acceptance for unsedated methods.
These findings support the potential integration of uTNE and VCE into routine BE screening protocols.