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Accessory Structures of the Skin: Sweat Glands

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...

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Related Experiment Video

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Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

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Development, structure, and keratin expression in C57BL/6J mouse eccrine glands.

D K Taylor¹, J A Bubier, K A Silva

¹The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.

Veterinary Pathology

|December 3, 2011

Summary

This summary is machine-generated.

This study details the development of mouse eccrine sweat glands from embryonic stages to postpartum. It provides a reference for skin research using genetically engineered mice.

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Area of Science:

Developmental biology
Dermatology
Mouse models

Background:

Eccrine sweat glands are crucial for thermoregulation in humans.
Mouse eccrine glands, located on footpads, offer a model for studying human gland development.

Purpose of the Study:

To characterize the developmental timeline and cellular differentiation of mouse eccrine sweat glands.
To provide a reference for researchers using mouse models in skin studies.

Main Methods:

Embryonic and postpartum mouse tissues were analyzed.
Immunohistochemistry was used to examine keratin expression patterns.

Main Results:

Eccrine gland anlagen appeared at 16.5 days postconception.
Specific keratin expressions (K1, K10, K14, K17, K5, K6) were mapped during development.
Gland maturation and duct development were observed up to 7 postpartum days.

Conclusions:

Mouse eccrine sweat gland development follows a defined pattern from embryonic to postpartum stages.
Keratin expression profiles provide insights into gland differentiation.
This research serves as a valuable reference for skin research utilizing mouse models.