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High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization
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VectorBase: improvements to a bioinformatics resource for invertebrate vector genomics.

Karine Megy1, Scott J Emrich, Daniel Lawson

  • 1European Bioinformatics Institute EMBL, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK. kmegy@ebi.ac.uk

Nucleic Acids Research
|December 3, 2011
PubMed
Summary

VectorBase offers expanded genomic data for invertebrate disease vectors, including new population biology resources for variation and resistance. This bioinformatics resource aids research on pathogen-carrying insects and arthropods.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Vector Biology

Background:

  • VectorBase is a key bioinformatics resource for invertebrate vectors of human pathogens.
  • It currently hosts data for nine genomes, including mosquitoes, ticks, and flies.
  • Data types encompass genomic features, expression data, population genetics, and ontologies.

Purpose of the Study:

  • To describe improvements and new data integration in VectorBase.
  • To expand taxonomic coverage and enhance data visualization capabilities.
  • To introduce a new population biology resource for genomic variations and insecticide resistance.

Main Methods:

  • Integration of new genomic and related datasets.
  • Bi-monthly data releases and frequent genome browser updates.
  • Development of a population biology resource utilizing improved ontologies.

Main Results:

  • Expanded taxonomic coverage of invertebrate vectors.
  • Enhanced genome browser with improved visualization options.
  • New population biology resource for genomic variations and insecticide resistance data.

Conclusions:

  • VectorBase provides timely access to diverse data for invertebrate vectors.
  • New features facilitate the study of genomic variations and insecticide resistance.
  • Community engagement helps overcome bioinformatics and annotation challenges.