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Pulmonary involvement of Brucellosis: a report of six cases

F Simsek1, M T Yildirmak, H Gedik

  • 1Department of Infectious Diseases and Clinical Microbiology, Ministry of Health, Okmeydaný Training and Research Hospital, Istanbul, Turkey.

African Health Sciences
|December 3, 2011
PubMed
Abstract

Insights

Pulmonary brucellosis, though rare, presents with fever and cough. Combined antibiotic therapy, including doxycycline and rifampicin, offers a good prognosis for patients with this infection.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Microbiology

Background:

  • Brucellosis is a zoonotic disease with rare pulmonary involvement.
  • Pulmonary manifestations can arise from aerosol inhalation or hematogenous spread.

Observation:

  • This report details six cases of pulmonary brucellosis.
  • Patients presented with fever and cough, with varied radiological findings including consolidation, opacity, and pleural effusion.
  • Blood cultures confirmed Brucella spp. in three patients.

Findings:

  • Radiological findings included pneumonic patches, consolidation, bilateral glass opacity, increased peribronchial thickness, pleural effusion, emphysematous changes, and atelectasis.
  • Brucella species were identified in blood cultures of half the patients.
  • All patients achieved clinical improvement within 7-10 days with a six-week course of doxycycline and rifampicin, with one requiring eight weeks for hepatosplenic brucellosis.

Implications:

  • Pulmonary brucellosis, while uncommon, is treatable with appropriate antimicrobial regimens.
  • Early diagnosis and combined therapy are crucial for favorable outcomes.
  • This case series highlights the diverse pulmonary presentations and effective treatment strategies for brucellosis.
Keywords:
Brucellosismanifestationspulmonary

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