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Related Experiment Video

Updated: May 27, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

Visual function in patients on ethambutol therapy for tuberculosis.

Himal Kandel1, Prakash Adhikari, Gauri S Shrestha

  • 1Eye Care Clinic, S. Hithadhoo, Republic of Maldives. himalkdl@gmail.com

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Ethambutol therapy can cause subclinical visual changes. Visual acuity, contrast sensitivity, and multifocal electroretinography (ERG) detect early ocular toxicity in patients undergoing tuberculosis treatment.

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Last Updated: May 27, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Tuberculosis Treatment

Background:

  • Ethambutol is a first-line antituberculosis drug.
  • Ocular toxicity is a known side effect of ethambutol therapy.
  • Early detection of visual function changes is crucial for patient management.

Purpose of the Study:

  • To evaluate the impact of ethambutol therapy on visual functions.
  • To identify sensitive tests for detecting early ethambutol-induced ocular toxicity.

Main Methods:

  • Prospective study of 44 patients receiving ethambutol for tuberculosis.
  • Evaluated visual acuity, contrast sensitivity, color vision, visual fields, and multifocal electroretinography (ERG) before and after 2 months of therapy.
  • Included anterior and posterior segment examinations.

Main Results:

  • Significant changes in visual acuity and contrast sensitivity were observed post-ethambutol therapy.
  • Multifocal ERG showed reduced P1 amplitudes and increased P1 latencies, indicating functional impairment.
  • Color vision, visual fields, and ocular segments remained unaffected.

Conclusions:

  • Visual acuity, contrast sensitivity, and multifocal ERG are sensitive indicators of subclinical ethambutol ocular toxicity.
  • These tests are valuable for monitoring patients on ethambutol therapy.
  • Early detection aids in preventing irreversible visual damage.