Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Anti-CTLA-4 synergizes with dendritic cell-targeted vaccine to promote IL-3-dependent CD4<sup>+</sup> effector T cell infiltration into murine pancreatic tumors.

Annals of the New York Academy of Sciences·2019

Same author

Pillars Article: Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking. <i>Science</i>. 1998. 282: 480-483.

Journal of immunology (Baltimore, Md. : 1950)·2017

Same author

In vivo targeting of protein antigens to dendritic cells using anti-DEC-205 single chain antibody improves HIV Gag specific CD4<sup>+</sup> T cell responses protecting from airway challenge with recombinant vaccinia-gag virus.

Immunity, inflammation and disease·2017

Same author

Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.

PloS one·2016

Same author

ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis.

PloS one·2015

Same author

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.

The Journal of experimental medicine·2014

Search research articles

Related Experiment Video

Updated: May 27, 2026

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022

Decisions about dendritic cells: past, present, and future.

Ralph M Steinman¹

¹Laboratory of Cell Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA.

Annual Review of Immunology

|December 6, 2011

Summary

Dendritic cells are crucial for initiating adaptive immunity and tolerance. Understanding their function and maturation is key to developing new vaccines and therapies.

Area of Science:

Immunology
Cell Biology

Background:

The adaptive immune system relies on a complex network of cells to defend against pathogens and maintain self-tolerance.
Dendritic cells (DCs) are professional antigen-presenting cells critical for bridging innate and adaptive immunity.

Observation:

DCs are essential for energizing and directing the adaptive immune response.
DCs exhibit a remarkable diversity, tolerance, and appropriate response to various challenges.
The in vivo distribution and development of DCs, a distinct white blood cell lineage, are increasingly understood.

Findings:

DCs play a central role in initiating antigen-specific immunity and tolerance.
DC maturation is vital for linking innate and adaptive immune responses to diverse stimuli.
Antigen uptake receptors on DCs are a focus for targeted therapies and vaccine development.

More Related Videos

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Related Experiment Videos

Last Updated: May 27, 2026

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Implications:

Advances in dendritic cell science offer new avenues for vaccine design and immunotherapy.
Targeting DC antigen uptake provides novel strategies for preclinical and clinical applications.
A deeper understanding of DC biology enhances our ability to combat infections and autoimmune diseases.