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Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Recent derivatives from smaller classes of fermentation-derived antibacterials.

Herbert A Kirst¹

¹Eli Lilly and Co. (ret.), 7840 West 88th Street, Indianapolis, IN 46278, USA. herbertkirst1@comcast.net

Expert Opinion on Therapeutic Patents

|December 6, 2011

Summary

New strategies are exploring older antibiotic classes to combat drug-resistant infections. Research into fermentation-derived compounds is yielding promising clinical candidates for treating challenging bacterial pathogens.

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Area of Science:

Microbiology
Medicinal Chemistry
Drug Discovery

Background:

Urgent need for novel antibiotics to combat antimicrobial resistance.
Exploration of underutilized fermentation-derived antibiotic classes.
Development of new derivatives and analogs through medicinal chemistry and biosynthetic pathway manipulation.

Purpose of the Study:

To review recent advancements in discovering new antibacterial derivatives.
To highlight the potential of underinvestigated natural product antibiotic classes.

Main Methods:

Literature review of patents and journals from 2007 to present.
Focus on new antibacterial derivatives from fermentation-derived sources.

Main Results:

Several programs have yielded clinical candidates in preclinical or early clinical trials.
Renewed investigations demonstrate potential for discovering new clinical candidates.

Conclusions:

Underdeveloped fermentation-derived antibiotic classes offer significant potential for new drug discovery.
Exploring underinvestigated natural products is a viable strategy to combat resistant pathogens.
New antibiotics are crucial additions to the physician's armamentarium.