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08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[Renal failure in sarcoidosis].
B Hadj Sadek1, Z Sqalli, Z Al Hamany
1Service de néphrologie-dialyse et transplantation rénale, CHU Ibn Sina, Rabat, Maroc. bahaahadjsadek@yahoo.fr
Revue De Pneumologie Clinique
|December 6, 2011
Summary
Renal sarcoidosis, a rare cause of kidney failure, often presents as granulomatous interstitial nephritis. Early corticosteroid treatment can significantly improve renal function and prevent chronic kidney disease progression.
Area of Science:
- Nephrology
- Rheumatology
- Pulmonology
Background:
- Renal sarcoidosis is an uncommon condition, potentially leading to renal failure in under 3% of patients.
- It can manifest due to calcium metabolism disturbances or granulomatous interstitial nephritis.
Purpose of the Study:
- To report on five cases of renal failure secondary to sarcoidosis over a nine-year period.
- To evaluate the efficacy of corticosteroid therapy in managing renal sarcoidosis.
Main Methods:
- Retrospective analysis of five patients diagnosed with renal sarcoidosis.
- Renal biopsy to confirm granulomatous interstitial nephritis.
- Treatment with prednisolone (1mg/kg/day), with some receiving methylprednisolone pulses.
Main Results:
- All five patients (3 males, 2 females; mean age 31.6 years) had granulomatous interstitial nephritis on biopsy.
- Pulmonary involvement was noted in three patients.
- Two patients achieved normalized creatinine levels, and all showed improved renal function after a mean follow-up of 52.6 months.
Conclusions:
- Renal involvement in sarcoidosis may be underdiagnosed.
- Corticosteroid therapy is effective in improving renal function and should be initiated early to prevent irreversible chronic kidney disease.
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