[Choice of therapy based on clinical setting]

Area of Science:

• Dermatology
• Clinical Therapeutics

Background:

• Psoriasis treatment selection is complex, involving patient and disease variables.
• Clinical trial criteria often exclude patients with special psoriasis forms or comorbidities managed in real-world settings.

Purpose of the Study:

• To provide evidence-based therapeutic recommendations for psoriasis management.
• To address the complexities of psoriasis therapy choice in diverse patient populations.

Main Methods:

• Critical analysis of existing literature on psoriasis therapies.
• Incorporation of expert clinical practice and real-world patient data.

Main Results:

• Identified key patient-related factors: age, pregnancy, desire for children, organ failure, infection/neoplasia risk, comorbidities (metabolic, cardiovascular, psychiatric), compliance, and lifestyle.
• Highlighted disease-related factors: unstable lesions, acral sites, erythrodermic, pustular, guttate psoriasis, and psoriatic rheumatism.

Conclusions:

• Therapeutic decisions for psoriasis must integrate patient-specific and disease-specific elements.
• Expert recommendations aim to guide effective psoriasis management beyond clinical trial parameters.