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Related Experiment Video

Updated: May 27, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Validation of a 3D computational fluid-structure interaction model simulating flow through an elastic aperture.

A Quaini¹, S Canic, R Glowinski

¹Department of Mathematics, University of Houston, Houston, TX, USA. quaini@math.uh.edu

Journal of Biomechanics

|December 6, 2011

Summary

This study validates a computational model for mitral valve regurgitation, showing excellent agreement between simulation and experimental data for flow rate, pressure, and valve displacement.

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Published on: July 19, 2016

Area of Science:

Biomedical Engineering
Computational Fluid Dynamics
Cardiovascular Research

Background:

Mitral valve regurgitation (MVR) involves complex intracardiac flow events.
3D echocardiography is emerging for MVR imaging, requiring computational support.
Accurate computational models are crucial for refining MVR diagnosis and treatment.

Purpose of the Study:

To validate a 3D computational fluid-structure interaction (FSI) model of MVR.
To assess the model's accuracy in simulating blood flow and valve dynamics.
To support the development of advanced echocardiographic techniques for MVR.

Main Methods:

Developed a 3D FSI computational model using a semi-implicit, monolithic method and arbitrary Lagrangian-Eulerian approach.
Modeled the regurgitant mitral valve as an elastic plate and blood flow using 3D Navier-Stokes equations.
Coupled fluid and structure dynamics via kinematic and dynamic conditions for two-way interaction.

Main Results:

Experimental measurements of flow rate, pressure, and valve displacement were compared to simulation results.
Maximum differences were 4% for flow rate, 3.6% for pressure, and 15% for orifice displacement.
Demonstrated excellent agreement between the computational model and in vitro experimental data.

Conclusions:

The validated 3D FSI model accurately simulates MVR conditions.
This model can aid in understanding and imaging MVR using 3D echocardiography.
The findings support the use of computational modeling in cardiovascular research and clinical applications.