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α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2

Jacque P K Ip1, Lei Shi, Yu Chen

  • 1Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Nature Neuroscience
|December 6, 2011
PubMed
Summary

α2-chimaerin is crucial for guiding brain neuron migration and function. Its disruption leads to developmental defects and increased seizure susceptibility in mice, revealing a new mechanism for neurodevelopmental disorders.

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