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High long-term local control with sacrectomy for primary high-grade bone sarcoma in children
Alexandre Arkader1, Christine H Yang, Vernon T Tolo
1Bone and Soft-Tissue Tumors Program, Children's Orthopaedic Center, Children's Hospital Los Angeles; Keck School of Medicine, University of Southern California, 4650 W Sunset Blvd., Mailstop #69, Los Angeles, CA 90027, USA. aarkader@chla.usc.edu
Sacrectomy can achieve local control for pediatric bone sarcomas, offering potential for long-term survival and quality of life despite complications. This study evaluated oncologic outcomes and functional recovery in children undergoing sacrectomy.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Orthopedic Oncology
Background:
- Sacrectomy is a potential curative treatment for primary sacral sarcomas.
- Local control rates after sacrectomy for these tumors are not well-established.
Purpose of the Study:
- To determine the curative potential of sacrectomy for pediatric primary bone sarcomas.
- To assess functional outcomes including walking ability, continence, and quality of life post-surgery.
Main Methods:
- Retrospective review of eight children with high-grade primary bone sarcomas treated with sacrectomy.
- Analysis of local/distant recurrences, survival, functional scores (MSTS), ambulation, continence, and complications.
- Average follow-up of 80 months.
Main Results:
- Six of eight patients survived with no evidence of disease.
- Seven patients could ambulate, with two independent.
- Neurologic deficits and complications were common, with seven of eight patients experiencing complications, five requiring further surgery.
Conclusions:
- Sacrectomy achieved local control in pediatric high-grade bone sarcomas.
- Despite high complication rates, long-term survival and adequate quality of life are achievable.
- Further research into managing complications and improving functional outcomes is warranted.
