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Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Primary Active Transport01:29

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would not...
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.

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Related Experiment Video

Updated: May 27, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

MetaBase--the wiki-database of biological databases.

Dan M Bolser1, Pierre-Yves Chibon, Nicolas Palopoli

  • 1Personal Genomics Institute, Genome Research Foundation, Suwon 443-270, South Korea. dan.bolser@gmail.com

Nucleic Acids Research
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

MetaBase is a community-curated database organizing over 2000 biological databases. This resource helps researchers effectively find and utilize biological data, leveraging a Wikipedia-like platform for contributions.

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Area of Science:

  • Bioinformatics
  • Biological Databases
  • Data Management

Background:

  • The exponential growth of biological data necessitates efficient organization of public databases.
  • Existing resources require curation and rating for optimal exploitation by the scientific community.

Purpose of the Study:

  • To introduce MetaBase, a community-curated repository for biological databases.
  • To provide a searchable and browsable catalog of over 2000 biological resources.

Main Methods:

  • MetaBase utilizes MediaWiki technology, similar to Wikipedia, for community contributions and curation.
  • Database entries are structured with templates and support user annotations.
  • Content is initially derived from the Nucleic Acids Research Database Issue and supplemented by literature and user submissions.

Main Results:

  • MetaBase currently contains over 2000 commonly used biological databases.
  • The platform supports diverse user interactions including searching, listing, browsing, and querying.
  • The database is updated annually with the Nucleic Acids Research Molecular Biology Database Collection.

Conclusions:

  • MetaBase serves as a vital, community-driven resource for navigating the expanding landscape of biological databases.
  • Its collaborative nature ensures continuous growth and relevance for biological research.