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Determination of influenza virus proteins required for genome replication
T S Huang1, P Palese, M Krystal
1Department of Microbiology, Mt. Sinai School of Medicine, New York, New York 10029-6574.
Journal of Virology
|November 1, 1990
Abstract:
An artificial vaccinia virus vector-driven replication system for influenza virus RNA has been developed. In this system, a synthetic NS-like gene is replicated and expressed by influenza virus proteins supplied through infection with vaccinia virus recombinant vectors. The minimum subset of influenza virus proteins needed for specific replication and expression of the viral ribonucleoprotein was found to be the three polymerase proteins (PB1, PB2, and PA) and the nucleoprotein.