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Pharmacological hyperprolactinaemia.

Maithili Srikantha1, Richard Butterworth

  • 1Milton Keynes Hospital NHS Foundation Trust, Department of Medicine, Standing Way, Eaglestone, Milton Keynes, Buckinghamshire, MK6 5LD, UK.

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|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Metoclopramide, a medication for irritable bowel syndrome, can cause elevated prolactin levels (hyperprolactinaemia) by blocking dopamine. Stopping the drug quickly resolved the patient's symptoms and normalized prolactin.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Neurology

Background:

  • A patient presented with hyperprolactinaemia and oligomenorrhoea.
  • The patient was taking metoclopramide for irritable bowel syndrome symptoms.

Purpose of the Study:

  • To investigate the cause of elevated prolactin levels in a patient.
  • To highlight medication side effects as a cause of hyperprolactinaemia.

Main Methods:

  • Assessed patient history and medication.
  • Monitored prolactin levels after medication cessation.

Main Results:

  • Metoclopramide, a dopamine antagonist, was identified as the cause of elevated prolactin.
  • Discontinuation of metoclopramide led to rapid normalization of prolactin levels.

Conclusions:

  • Medication-induced hyperprolactinaemia is a significant consideration.
  • Non-pathological causes, including drug interactions, should be evaluated for elevated prolactin.