Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

Overview
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...
Evolutionary Psychology01:20

Evolutionary Psychology

Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the human psyche...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injectable Thermosensitive Placental ECM-Copper Hydrogel With Endothelial Progenitor Cells for Pressure Ulcer Repair.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same author

Advanced extracellular vesicle therapeutics: From molecular engineering to intelligent devices.

Acta biomaterialia·2026
Same author

Biomimetic hydrogels integrated with strontium and zinc co-substituted mesoporous silica nanoparticles with osteo-immunomodulatory and osteo-angiogenic functions for advanced bone regeneration.

Biomaterials advances·2026
Same author

3D-printed functional engineered intestinal models.

Journal of materials chemistry. B·2026
Same author

Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy.

Research square·2026
Same author

PID-controller enhanced artificial β-cells.

PloS one·2026

Related Experiment Video

Updated: May 26, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

Optimizing cross-reactivity with evolutionary search for sensors.

Kyung-Ae Yang1, Renjun Pei, Darko Stefanovic

  • 1Division of Experimental Therapeutics, Department of Medicine, Columbia University, New York, New York 10032, USA.

Journal of the American Chemical Society
|December 7, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed an evolutionary method to create DNA sensor arrays for accurately classifying steroids. This approach enables precise discrimination between different steroid classes, offering a novel diagnostic tool.

More Related Videos

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

Related Experiment Videos

Last Updated: May 26, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genomics

Background:

  • Developing selective biosensors is crucial for molecular diagnostics.
  • DNA-based sensors offer unique interaction capabilities.
  • Classifying complex molecular mixtures like steroids requires high specificity.

Purpose of the Study:

  • To devise a straightforward evolutionary procedure for constructing an optimal DNA sensor array.
  • To achieve perfect classification of individual steroids using a sensor array.
  • To demonstrate discriminatory capacity between steroid classes across concentration ranges.

Main Methods:

  • Mining DNA sequences oriented toward three-way junctions from a larger pool.
  • Applying separate selection pressures to individual sensors for steroid interaction.
  • Allowing controlled cross-reactivity to enhance classification accuracy.
  • Assembling a three-sensor array for steroid analysis.

Main Results:

  • An optimal sensor array was successfully constructed using the evolutionary procedure.
  • The sensor array demonstrated discriminatory capacity between steroid classes.
  • Accurate classification of individual steroids was achieved across full concentration ranges.
  • The array comprised three distinct DNA sensors.

Conclusions:

  • The reported evolutionary procedure is effective for building optimal DNA sensor arrays.
  • This method can be applied to classify samples with distinct component ratios.
  • The developed sensor array offers a robust tool for steroid analysis and potentially other molecular classification tasks.