Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute effects of low-dose bisoprolol on lung function and blood pressure in COPD patients.

ERJ open research·2026
Same author

Shaping lung health from the start: early-life trajectories and lifelong risk.

The European respiratory journal·2026
Same author

Social mobility and parenting: Testing associations in a prospective longitudinal cohort study.

Child development·2026
Same author

Bisoprolol to prevent adverse cardiac events (PACE) in COPD: a multicentre, double-blind, randomised, controlled, phase 3 trial.

The Lancet. Respiratory medicine·2026
Same author

Cost-effectiveness of as-needed budesonide-formoterol in adults with mild asthma: the Novel START trial.

ERJ open research·2026
Same author

Preconception Predictors of Next Generation Early Relational Health: A Living Review of Prospective Cohort Studies.

Clinical child and family psychology review·2025

Related Experiment Video

Updated: May 26, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Asthma phenotypes: consistency of classification using induced sputum.

Robert J Hancox1, Douglas C Cowan, Ruth E Aldridge

  • 1Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, UK. bob.hancox@otago.ac.nz

Respirology (Carlton, Vic.)
|December 7, 2011
PubMed
Summary

Asthma phenotypes, classified by sputum eosinophils, are unstable over time and with treatment. A single sputum sample is insufficient for diagnosing non-eosinophilic asthma.

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Quality-Controlled Sputum Analysis by Flow Cytometry
07:22

Quality-Controlled Sputum Analysis by Flow Cytometry

Published on: August 9, 2021

Related Experiment Videos

Last Updated: May 26, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Quality-Controlled Sputum Analysis by Flow Cytometry
07:22

Quality-Controlled Sputum Analysis by Flow Cytometry

Published on: August 9, 2021

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Asthma classification into eosinophilic and non-eosinophilic phenotypes guides corticosteroid treatment.
  • Sputum cell profiling is key to determining these asthma phenotypes.

Purpose of the Study:

  • To assess the stability of asthma phenotypes (eosinophilic vs. non-eosinophilic) over time.
  • To evaluate how different treatment regimens affect asthma phenotype classification.

Main Methods:

  • Two studies analyzed induced sputum cell counts in stable, non-smoking adults with asthma.
  • Study one examined phenotype changes after placebo, beta-agonist, corticosteroid, and combination treatments.
  • Study two assessed phenotype stability during placebo and corticosteroid washout periods.

Main Results:

  • Asthma phenotypes frequently changed in both studies.
  • In study one, most participants with non-eosinophilic asthma shifted phenotypes.
  • In study two, all participants initially classified as non-eosinophilic had at least one eosinophilic sample.

Conclusions:

  • The phenotypic classification of asthma is dynamic and changes frequently.
  • Diagnosing non-eosinophilic asthma requires multiple sputum samples, not just one.
  • Treatment regimens can influence observed asthma phenotypes.