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Related Experiment Video

Updated: May 26, 2026

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Published on: October 11, 2019

Case report: Peripheral polyneuropathy and mefloquine prophylaxis.

Alexander C Chester¹, Paola Sandroni

¹Department of Medicine, Georgetown University Hospital, Washington, DC 20016, USA. achester@foxhallinternists.com

The American Journal of Tropical Medicine and Hygiene

|December 7, 2011

Summary

A woman developed peripheral polyneuropathy after taking mefloquine hydrochloride for malaria prevention. This rare adverse effect, affecting peripheral nerves, is seldom documented following mefloquine use.

Related Experiment Videos

Last Updated: May 26, 2026

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Published on: October 11, 2019

Area of Science:

Neuroscience
Pharmacology
Tropical Medicine

Background:

Mefloquine hydrochloride is a common antimalarial drug.
Central nervous system side effects of mefloquine are well-documented.
Peripheral neuropathy is a less common but serious adverse event.

Observation:

A case of peripheral polyneuropathy is presented in a woman after completing malaria prophylaxis with mefloquine hydrochloride.
The patient received 4 weekly doses of 250 mg mefloquine hydrochloride.
The onset of symptoms occurred shortly after the completion of the prophylactic regimen.

Findings:

The presented case highlights a rare instance of peripheral polyneuropathy potentially linked to mefloquine hydrochloride.
This specific presentation of peripheral nerve involvement is seldom reported in medical literature.
The neurological complication manifested as peripheral polyneuropathy, distinct from more common central nervous system effects.

Implications:

This case underscores the importance of considering peripheral polyneuropathy in patients presenting with neurological symptoms after mefloquine use.
Further research may be warranted to elucidate the mechanisms underlying mefloquine-induced peripheral polyneuropathy.
Clinicians should be vigilant for rare neurological adverse events associated with mefloquine prophylaxis.