Related Experiment Video
Updated: Jun 6, 2026
08:21
Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
Published on: July 21, 2023
Anhidrosis: An underappreciated factor in dermatologic diseases.
Gabrielle F Lutz1, Mark Denis P Davis2, Paola Sandroni3
1Indiana University School of Medicine, Fort Wayne, Indiana.
Journal of the American Academy of Dermatology
|June 5, 2026
Summary
Anhidrosis, or lack of sweating, impairs body heat dissipation, increasing heat-related illness risk. Recognizing anhidrosis is crucial for dermatologists managing patients with skin symptoms and heat intolerance.
Area of Science:
- Dermatology
- Thermoregulation
- Human Physiology
Background:
- Sweating is vital for body heat dissipation.
- Impaired sweating (hypohidrosis or anhidrosis) can overwhelm thermoregulation.
- This can lead to dangerous heat-related illnesses like heat stroke.
Purpose of the Study:
- To review the dermatologic literature on anhidrosis.
- To explore its link to skin diseases and symptoms.
- To discuss diagnostic tools and management strategies.
Main Methods:
- Literature review of dermatologic studies on anhidrosis.
- Analysis of the relationship between anhidrosis and skin symptoms.
- Examination of current diagnostic and management approaches.
Main Results:
- Anhidrosis is linked to heat intolerance and various skin symptoms.
- Symptoms include flushing syndromes and widespread sensations like itching and paresthesias.
- Diagnosing anhidrosis can be challenging due to limited tools.
Conclusions:
- Dermatologists should consider anhidrosis in patients with heat-related symptoms and specific skin conditions.
- Early recognition of anhidrosis is key for effective patient management.
- Further research into diagnostic tools and pathophysiology is warranted.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:20Accessory Structures of the Skin: Sweat Glands
Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:28Factors Affecting Body Temperature
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
01:30Assessment of Airway, Skin Color, and Use of Accessory Muscles
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
Introduction
The initial evaluation of a patient's respiratory system...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...