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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 26, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Cancer cachexia.

Raghu Dhanapal1, Tr Saraswathi, Rajkumar N Govind

  • 1Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|December 7, 2011
PubMed
Summary
This summary is machine-generated.

Cancer cachexia is a complex wasting syndrome impacting cancer patients. This review explores its multifactorial mechanisms and specifically examines cachexia in head and neck cancers.

Keywords:
Cachexiahead and neck cancertissue wastingwasting syndrome

Related Experiment Videos

Last Updated: May 26, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

  • Oncology
  • Metabolic Disorders

Background:

  • Cancer cachexia is a debilitating syndrome marked by significant weight loss, anorexia, asthenia, and anemia.
  • Its development involves intricate interactions between tumor and host factors, making it a critical prognostic indicator.

Purpose of the Study:

  • To review the diverse mechanisms underlying cancer cachexia.
  • To provide specific insights into the manifestation of cachexia in head and neck cancer patients.

Main Methods:

  • Literature review focusing on cancer cachexia.
  • Analysis of studies detailing tumor-host interactions in cachexia.
  • Examination of case studies and research on head and neck cancers.

Main Results:

  • Cachexia pathogenesis is multifactorial, involving complex tumor and host interactions.
  • Clinical signs of cachexia are significant prognostic parameters in cancer management.
  • Head and neck cancer presents unique challenges and mechanisms in cachexia development.

Conclusions:

  • Understanding cachexia mechanisms is crucial for improving cancer patient outcomes.
  • Targeting cachexia pathways may offer therapeutic benefits.
  • Further research into head and neck cancer cachexia is warranted.