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Cardiac function in 7-8-year-old offspring of women with type 1 diabetes

Maarten Rijpert1, Johannes M P J Breur, Inge M Evers

  • 1Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, 3508 AB Utrecht, The Netherlands. m.rijpert@umcutrecht.nl

Experimental Diabetes Research
|December 7, 2011
PubMed

Insights

Children born to mothers with type 1 diabetes show reassuring cardiac function at 7-8 years old. Neonatal size and maternal glucose control did not negatively impact their heart health.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pediatrics

Background:

  • Offspring of type 1 diabetic mothers (ODMs) face risks for neonatal macrosomia and later cardiovascular issues.
  • Cardiac outcomes in ODMs have not been previously studied.
  • Understanding long-term cardiac health in ODMs is crucial for preventative care.

Purpose of the Study:

  • To investigate cardiac dimensions and function in 7-8-year-old ODMs.
  • To assess the relationship between neonatal macrosomia, maternal glycemic control, and cardiac outcomes in ODMs.
  • To compare cardiac parameters in ODMs with a control group of children from nondiabetic mothers.

Main Methods:

  • Cardiac assessment of 30 ODMs and 30 controls aged 7-8 years.
  • Evaluation of cardiac dimensions, systolic, and diastolic function.
  • Analysis correlating cardiac outcomes with neonatal birth weight and maternal glycemic control during pregnancy.

Main Results:

  • Cardiac dimensions and function (systolic and diastolic) were comparable between ODMs and controls.
  • Neonatal macrosomia was not associated with adverse cardiac outcomes in ODMs.
  • Poorer maternal glycemic control during pregnancy did not correlate with worse cardiac function in ODMs.

Conclusions:

  • Cardiac function in 7-8-year-old ODMs is reassuring and similar to controls.
  • Early life factors like macrosomia and maternal glucose control do not appear to negatively impact cardiac health at this age.
  • This study provides valuable insights into the long-term cardiac well-being of children born to mothers with type 1 diabetes.

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