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Updated: May 26, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Three-component chiral derivatizing protocols for NMR spectroscopic enantiodiscrimination of hydroxy acids and
Sachin Rama Chaudhari1, N Suryaprakash
1Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.
Abstract:
The novel three-component chiral derivatization protocols have been derived for (1)H and (19)F NMR spectroscopic discrimination of a series of chiral hydroxy acids by their coordination and self-assembly with optically active α-methylbenzylamine and 2-formylphenylboronic acid. In addition, the optically pure (S)-mandelic acid in combination with 2-formylphenylboronic acid permits visualization of enantiomers of primary amines. These protocols have been demonstrated on enantiodiscrimination of chiral amines and hydroxy acids.
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