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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Updated: May 26, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Jun Mu1, Paul R Krafft, John H Zhang

  • 1Department of Physiology, Loma Linda University School of Medicine, 11021 Campus Street, Loma Linda, CA 92354, USA. johnzhang3910@yahoo.com.

Medical Gas Research
|December 8, 2011
PubMed
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Hyperbaric oxygen therapy (HBOT) may enhance adult neurogenesis, a natural repair process after central nervous system (CNS) injury. However, clinical evidence for HBOT

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Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
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Published on: November 18, 2013

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Last Updated: May 26, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

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Published on: May 31, 2017

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Area of Science:

  • Neuroscience and regenerative medicine, focusing on central nervous system (CNS) repair mechanisms.

Background:

  • Adult neurogenesis is a natural repair mechanism following CNS injury.
  • Hyperbaric oxygen therapy (HBOT) is hypothesized to enhance neurogenesis and improve functional outcomes post-CNS injury.

Discussion:

  • This review examines experimental and clinical studies on HBOT's effects on neurogenesis.
  • Hypothetical mechanisms involve HBOT influencing transcription factors like hypoxia-inducible factors (HIFs) and cAMP response element binding (CREB).

Key Insights:

  • A significant discrepancy exists between experimental findings and clinical trial results regarding HBOT's efficacy.
  • Current evidence does not conclusively support HBOT for enhancing neurogenesis in clinical settings.

Outlook:

  • Further translational preclinical research is essential to bridge the gap between lab findings and clinical application.
  • Improved, well-designed clinical trials are necessary to definitively assess the potential benefits of HBOT for CNS repair.