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Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Jun Mu1, Paul R Krafft, John H Zhang

  • 1Department of Physiology, Loma Linda University School of Medicine, 11021 Campus Street, Loma Linda, CA 92354, USA. johnzhang3910@yahoo.com.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...