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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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[Renal involvement in cancer and renal paraneoplastic syndromes]

Juliette Thariat1, Benoit Vendrely, Sophie Roca

  • 1Université Nice - Sophia-Antipolis, centre Antoine-Lacassagne, département de radio-oncologie, IBDC CNRS UMR, France. jthariat@hotmail.com

Bulletin Du Cancer
|December 8, 2011
PubMed
Abstract

Insights

Cancer patients frequently develop kidney problems, including paraneoplastic glomerulopathies and kidney failure. Early renal evaluation and monitoring are crucial for managing these serious complications.

Area of Science:

  • Nephrology
  • Oncology
  • Internal Medicine

Context:

  • Renal alterations are common in cancer patients but often underreported.
  • Neoplastic diseases can lead to diverse kidney complications.

Purpose:

  • To review and categorize renal manifestations associated with cancer.
  • To highlight the importance of recognizing paraneoplastic syndromes affecting the kidneys.

Summary:

  • Renal manifestations in cancer include specific and paraneoplastic types.
  • Common paraneoplastic issues include membranous glomerulonephritis, direct kidney involvement, and electrolyte imbalances.
  • Other complications comprise retroperitoneal fibrosis, microangiothrombotic disease, and tumor lysis syndrome.

Impact:

  • Emphasizes the need for systematic renal assessment in cancer patients.
  • Highlights that treatments may not guarantee full recovery from renal complications.

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