[Metronomic chemotherapy in 2011: update and perspectives]
Zineb Benbrahim1, Christophe Massard, Omar El Mesbahi
1CHU Hassan-II, service d'oncologie médicale, Fès, Maroc. zineb247@hotmail.com
Bulletin Du Cancer
|December 8, 2011
Summary
Metronomic chemotherapy, using low-dose conventional agents frequently, shows promise in cancer treatment by inhibiting angiogenesis. Combining it with other therapies may improve patient outcomes and survival.
Area of Science:
- Oncology
- Cancer Biology
- Pharmacology
Context:
- Angiogenesis is vital for tumor growth and metastasis.
- New anti-angiogenic therapies are under development.
- Metronomic chemotherapy is an emerging strategy.
Purpose:
- To review experimental and clinical studies on metronomic chemotherapy.
- To discuss the potential uses and limitations of this approach.
Summary:
- Frequent administration of low-dose cytotoxic agents exhibits anti-angiogenic activity.
- Clinical trials confirm metronomic chemotherapy's efficacy in improving clinical benefit and survival.
- Combination therapies (metronomic chemotherapy with hormonotherapy, angiogenesis inhibitors, radiotherapy) enhance efficacy.
Impact:
- Metronomic chemotherapy offers a promising strategy for cancer treatment.
- Further research and biomarker identification are crucial for optimizing its use.
- This approach holds potential for improved patient survival and quality of life.
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